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The impact of the hexapeptide in various experimental models, e.g., for Barnes maze, swim mazes as well as radial arm mazes were subsequently explored (Wright et al., 1993

10.1097/brs.0b013e3181624504 139 KrausP.LiK.SipesD.VardenL.YerdenR.HendersonA.et al (2019)

Schedule Mouse studies used twice daily intraperitoneal injection

Increased intestinal permeability precedes clinical onset of type 1 diabetes

This observation indicated that the peptide is unlikely to generate resistance, and thus continued influence of the peptide might result in a pronounced effect