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Within hours after cleaning, teeth become coated with a layer of salivary proteins, which can isolate antibacterial materials from bacteria, thereby reducing antimicrobial efficiency and long-term efficacy ( In addition to the two aforementioned oral-specific environmental resistance factors, the clinical translation of nanomaterials currently faces several challenges:(1) the long-term biosafety, biocompatibility, and functional durability of these nanomaterials within the oral cavity require rigorous assessment in live animal models and, ultimately, clinical trials ( in vitro

[Abstract]2026 May 15;24(1):395

Also, scaffolds must possess suitable mechanical properties that support cells and tissues and promote controlled drug delivery [115]

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Nature 621 , 373380 (2023)