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A significant change in pH affects the structure of all macromolecules, for instance, presence of a higher proportion of H + or low pH solution cleaves DNA double helix strands by protonating the DNA phosphodiester groups and consequently destabilizing the hydrogen bonds linking DNA nitrogenous bases guanine and cytosine (G-C) ( E

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2.9.2 Nerve conduction test Twelve weeks post-surgery, to evaluate nerve regeneration, compound muscle action potential (CMAP) amplitudes of the sciatic nerves were evaluated [36]

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