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Li Z, Brown MA

In cell studies, folate deficiency upregulates miR-22 and miR-149

Besides direct modulators of iGluR activity, strong candidates for future approaches to treating chronic excitotoxicity include specific inducers of EAAT2 to stimulate L-glu and L-asp uptake, inhibitors of system x to reduce L-glu release as well as compounds that aim to decrease extracellular L-glu by modulating KYN metabolism, e.g., KMO inhibitors