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PINK1 primes Parkin-Mediated ubiquitination of PARIS in dopaminergic neuronal survival

GLP-1 receptors respond in parallel, amplifying insulin secretion, slowing gastric emptying, and sending satiety signals through the vagus nerve and into the brainstem

not primarily appetite-driven (OUP Academic) Expected weight loss (this is where many people get misled) In major obesity trials: Semaglutide 2.4 mg weekly: ~14.9% mean weight loss at 68 weeks (STEP-1) (PubMed) Tirzepatide: ~15.0% to ~20.9% mean weight loss at 72 weeks , dose-dependent (SURMOUNT-1) (PubMed) AOD-9604s best-known human signal is kilograms, not double-digit percentages , and later studies did not sustain a strong obesity-drug profile

Neuropharmacology 207:108966 Luo A et al (2022) Association between metformin and Alzheimers disease: a systematic review and meta-analysis of clinical observational studies