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Current research trends in NOX inhibitors focus on creating compounds that are both highly effective and specific to individual isoforms, as shown in Figure 2 (Dustin et al., 2023)

This is supported by large-scale cohort studies that identified increased plasma lactate in BD patients (e.g., FACE-BD and I-GIVE cohorts, 837 and 237 BD patients, respectively) [2]

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3.2.1 PINK1/Parkin mediated mitophagy The pathway consisting of PINK1 and Parkin is a key participant in mitophagy, as well as the most common and classical pathway of autophagic mitochondria (Wang et al., 2023)