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Front Immunol (2021) 12

Dual starvations induce pyroptosis for orthotopic pancreatic Cancer therapy through simultaneous deprivation of glucose and glutamine

C., Slaga, T

Upon catalysis of COXs, dihomo--linolenic acid (DGLA) and arachidonic acid (AA) can be oxidized by radical-mediated lipid peroxidation and produce prostaglandins, which linking the lipid peroxidation directly to inflammation and apoptotic processes [32,33,34]

Such a system is provided by glutathione reductase, which catalyzes the reduction of GSSG by NADPH, a product of the pentose phosphate pathway (Fig 5.27)