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Despite the efficacy of mTOR inhibitors in reducing primary tumor growth and CSC activity, lung metastasis remain resistant to treatment, indicating distinct mechanisms driving metastasis compared to primary tumor growth in ER + mammary carcinomas exposed to high collagen density [15]

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Significantly, enhanced transamination and aspartate synthesis in K-Ras-driven cancer cells are important in the promotion of nucleotide biosynthesis 184 and maintenance of redox balance 29