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10.1111/j.1460-9568.2005.04584.x 18 ChanD

A total of 132 participants were enrolled across both trials: 96 patients in the investigator-initiated trial and 36 patients in the Phase I trial

By binding to IGFBPs, IGF-1 markedly extend its half-life in circulation and prevent its binding to the IR, thereby allowing for more precise IGF-1 actions