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The liver enzyme ASS1 has also been suggested as a specific indicator of liver injury in mouse models

doi: 10.1002/JLB.3HI0220-130 14 BasitFMathanTSanchoDde VriesIJM

Neutralizing antibody against PAI-1 attenuated p65 activation in IL-1 treated hepatocytes and blocked PAI-1 induction completely, suggesting the freely released PAI-1 is required to fully activate p65 and induce PAI-1