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Leukodystrophies can affect people at any stage of their life, and currently have limited treatment options and no cure

Therefore, the reaction periods were extended to 168 h in the third and fourth reactions and 216 h in the fifth reaction

HSP90 inhibitors such as ganetespib (STA-9090) and AUY922 have been extensively evaluated in oncology, 54,55 where they disrupt the stabilization of oncogenic client proteins