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In animal models, ranging from invertebrates to non-human primates (NHP), studies have demonstrated that GAs have the capacity to inflict a range of temporary and permanent cognitive dysfunctions, as well as lasting structural impairments including increased cell death, suppressed neurite growth, and altered synapse formation (414)

In another study, nicotinic acid affected the hepatic uptake of ApoAI lipoprotein, thereby reducing high-density lipoprotein (HDL) removal from the circulation (reviewed in 20)

Another study investigating metabolomic profiles in murine macrophages treated with iron show increased levels of NADPH and 6-phosphogluconic acid, indicating the potential involvement of other factors, in addition to HIF1, in the iron-mediated regulation of the PPP (195)

After the fasting period, the use of food from soft and easy to digest food gradually over to ordinary meals

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