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In addition, the CPZ intoxication in our study caused neuronal injury evidenced by pyknotic oligodendroglial cells surrounded by highly edematous stroma in CTX, necrotic neurons with dense pyknotic nuclei surrounded by markedly degenerated edematous stroma in HC and degenerated nerve fibers and pyknotic nuclei in corpus callosum

In db/db mice, administration of M-920, a caspase inhibitor, reduced renal CASP1, IL-1, IL-18, and NLRP3 inflammasome activation, leading to amelioration of albuminuria and renal ECM accumulation (198)

doi: 10.1046/j.1523-1755.2000.07702.x 5

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doi: 10.1056/NEJMcp1803290 30 DammeijerFvan GulijkMMulderEELukkesMKlaaseLvan den BoschTet al