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Description

Oxidative stress in human pathology and aging: molecular mechanisms and perspectives

10.1038/s41467-019-09963-8 124 UtamaA.WijesingheR.ThngS

Glutamine antagonism, aiming to disrupt tumor growth by targeting critical metabolic pathways, is challenged by the adaptive nature of cancer cells and the complex metabolic microenvironment, potentially compromising its therapeutic efficacy