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Parenteral administration is typically used to treat vitamin B12 deficiency caused by pernicious anemia as well as other conditions (e.g., tropical sprue, pancreatic insufficiency) that result in vitamin B12 malabsorption and severe vitamin B12 deficiency

Subjects with the lowest levels of MMA were overwhelming less likely to experience migraines

People can have low vitamin B6 levels due to various reasons, like consuming less than required, poor absorption in the gut, problems with liver and kidney function, lack of adequate nutrition, and certain drug reactions

UK B12 treatment for B12 deficiency without neuro symptoms is 6 loading jabs over 2 weeks followed by a jab every 3 months for B12 deficiency with neuro symptoms present, it is a B12 loading jab every other day for as long as symptoms continue to get better (could mean loading jabs for weeks even months) then a jab every 2 months UK b12 documents BMJ B12 article bmj.com/content/349/bmj.g5226 BSH Cobalamin and Folate Guidelines b-s-h.org.uk/guidelines/gui