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In 6-hydroxydopamine (6-OHDA)-induced PD models, Bax knockdown significantly reduces dopaminergic neuron loss, while Bax overexpression exacerbates mitochondrial damage and apoptosis [34, 35]

Chronic Acetaminophen Toxicity

In our study, metabolomics based on UPLC-Orbitrap-MS/MS analysis method was applied to investigate the changes in fecal metabolites

To investigate whether activation of the IGF1/IGF1r axis in a mouse model of chronic migraine affects pain behavior, mice were intraperitoneally injected with the IGF1r antagonist (40 mg/kg/day) two hours prior to intraperitoneal injection of nitroglycerin (NTG) (Fig

Stress-induced glucocorticoids alter the Leydig cells timing and steroidogenesis-related systems