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A phase 1, multicenter, open label, single-ascending dose study to evaluate safety, tolerability, and pharmacokinetics of AP-101 in familial and sporadic amyotrophic lateral sclerosis (ALS) (4484)

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As an alternative strategy, patient-derived somatic cells as well as patient-independent cell lines were used to model specific aspects of the disease in vitro

While the redox and electrophilic response cis elements have been identified, less has been done to identify the signaling mechanisms that activate the transcription factors that bind to those elements