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TRPs are non-selective cation channels, most of which are permeable to Ca 2+ , which is a well-established second messenger that modulates several intracellular signaling pathways and is involved in physiological and pathological conditions in various cell types

In 2 compartment models, where the drug equilibrates between blood and (for example) adipose tissue, during elimination there is a sharp initial fall in blood levels followed by a gradual subsequent fall

Clinical testing should follow a molecularly triaged algorithm anchored in reproducible assays

The sorting, transport, and release of BDNF are essential for its function in neuronal development and synaptic plasticity

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