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Relevant role of neutrophils in oxidative stress

128 Notably, inhibiting lactylation at K215 and K224 on canopy FGF signaling regulator 3 (CNPY3), a key regulator of protein folding in the endoplasmic reticulum, compromises the formation of the CNPY3 complex with auxiliary molecular chaperones for protein folding and lysosomal transport, thereby affecting its cellular localization and promoting lysosome rupture and pyroptosis in prostate cancer cells

PMN-MDSCs are defined as CD11b + , CD33 + , CD14 , CD15 + (or CD66b + ), HLA-DR , while M-MDSCs express CD11b + , CD33 + , CD14 + , CD15 , HLA-DR /low

[DOI] [PMC free article] [PubMed] [Google Scholar] 182.Alsharairi N.A

A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl()/H(+) transport cycle