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[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Schwarz K, De Giuli R, Schmidtke G, Kostka S, van den Broek M, Kim KB, Crews CM, Kraft R, Groettrup M

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Copper toxicity and deficiency: the vicious cycle at the core of protein aggregation in ALS

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Future investigations should prioritize delineating the underlying molecular and cellular mechanisms, refining formulation and delivery platforms to overcome bioavailability constraints, and implementing rigorously designed, adequately powered clinical trials across diverse populations