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Philadelphia: Saunders/Elsevier

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doi:10.1136/postgradmedj-2021-140336

These landmark studies showed that mice with adipose-tissue-specific NNMT knockout remained lean when fed high-fat diets that caused wild-type mice to become obese, and that these protected mice had increased energy expenditure, enhanced fatty acid oxidation, improved glucose tolerance, and elevated NAD+ levels in adipose tissue

The cut-off between normal vitamin B12 levels and deficiency varies by method and laboratory, but most laboratories define subnormal serum or plasma values as those lower than 200 or 250 pg/mL (148 or 185 pmol/L)