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An involvement of TRPM2 activation in H 2 O 2 -induced cell death was also evidenced by siRNA-mediated knockdown of Trpm2 in non-neuronal cells, such as immortalized mouse embryonic fibroblasts (Zou et al., 2013)

Several additional findings of this phase 1 study warrant discussion

This approach allows patients to establish baseline responses before introducing more complex protocols

doi: 10.1111/and.13584 34 GhasemiHKarimiJGoodarziMTKhodadadiITavilaniHMoridiHet al

The second trial, conducted at Peking University Third Hospital (Ethical code: D2020188), was a Phase I clinical triala randomized, double-blind, controlled study aimed at assessing the safety and preliminary efficacy of DPSC therapy at varying dose concentrations, carried out from July 31, 2021, to December 24, 2022