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AGE/RAGE action on vascular smooth muscle cells (VSMC) induces autophagy through the ERK/Akt pathway 454 and increases ROS and NOS levels through activation of NOX and NF-B, 455,456 increases oxidative stress, and accelerates atherosclerotic plaque progression

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Hong et al.[77] showed that EF extract promoted melanogenesis by upregulating the expression of TYR, TRP-1, and DCT through the MAPK/ERK1/2 signalling pathway

BPC-157 was first isolated from body protection compound (BPC), which is found in the gastric juices and is part of the digestive process