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534,535 Resting membrane of aged astrocytes remains highly hyperpolarised (~80 mV), the input resistance increases somewhat with age, thus reflecting morphological shrinkage

Evidence from animal research suggests the combination of alcohol and endotoxin can quickly raise levels of inflammatory cytokines in the blood, liver, and brain (Gonzalez-Reimers 2014)

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Moreover, the interpretation of biomarker responses is complicated by the poor bioavailability and limited bloodbrain barrier penetration of many phytochemicals