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Loss-of-function alterations in KEAP1 (or activating mutations in NRF2) allow tumor cells to hijack this pathway, leading to constitutive NRF2 activation, elevated antioxidant defenses (for example, GSH biosynthesis and detoxification enzymes) and enhanced tolerance to chemotherapy-induced oxidative injury 15

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Herbal medications are those made from bits or unprocessed extracts of plants having diverse constituents that interact synergistically [13] and the practice of using plants or plant-based materials for their therapeutic or medical benefits is known as herbal medicine or herbalism [14]