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As scientists and physicians, we love to push the limits of what is knownyet we must guide our patients in the safe and logical application of biologic therapies

223 , 224 , 225 , 226 In conclusion, the gut-brain axis plays an important role in the pathogenesis of PD, and in-depth study of the relevant mechanisms of the gut-brain axis will not only help us better understand the pathogenesis of PD but also may provide a theoretical basis for the development of new treatment strategies

In this review, we explore the complex interplay between sleep, metabolism, and aging across five core themes: (1) the role of sleep in maintaining optimal free radical levels, (2) whether ROS directly contribute to or mediate sleep disturbances in aging, (3) how age-related sleep disturbances may, in turn, contribute to impaired brain metabolism and exacerbate age-related changes, (4) the role of sleep, redox, and aging in peripheral systems, and (5) the evidence that improving mitochondrial redox potential restores sleep and slows aging, as well as the potential benefits of interventions like exercise, antioxidant-rich foods, supplements, and specialized diets that enhance sleep and/or metabolic efficiency, and their effects on aging markers (summarized in Figure 1)

It also covers the present, past, and future aspects to depression

Of particular interest in the present study is that AMPK activation appears to be, at least partially, redox-associated