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The intermittent schedule reflects the "hit-and-clear" nature of senolytic therapy -- once apoptosis is triggered, the immune system needs time to phagocytose debris

As a result, Im not going to recommend a specific model here

HOPDs would have approximately 25 months from the publication of this final rule with comment period until the start of the mandatory reporting period in January 2028, and approximately 3.5 years from the publication of this final rule with comment period until the submission deadline for the CY 2028 data in May 2029, to implement any workflow modifications or organizational updates necessary to successfully report on the measure

Jakkampudi A, Jangala R, Reddy BR, Mitnala S, Nageshwar Reddy D, Talukdar R

This way, patients can make smart choices about their care and avoid risks