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1 case of aggressive behavior, night terrors, trouble focusing - history of this, but seemed to worsen 1 case of aggressive behavior, moody - history of this, but seemed to worsen 1 case of nausea/diarrhea at lowest dose (person had long history of having similar reactions to almost all vitamin supplements) Some mild temporary adverse effects were reported in both the supplement and placebo group, generally related to mild behavior problems (approximately 11% and 7%, respectively) or diarrhea/constipation (approximately 11% and 7%, respectively), but did not cause participants to withdraw

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Inhibition of high-mobility group box 1 improves myocardial fibrosis and dysfunction in diabetic cardiomyopathy