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Furthermore, the depletion of glucocorticoids, through removal of the adrenal gland, resulted in an increase in adult hippocampal neurogenesis and removed stress-induced suppression of cell proliferation in the hippocampus [145]

However, their clinical benefits remain modest and variable, and their use is associated with safety concerns such as amyloid-related imaging abnormalities (ARIA), costly treatment, and invasive administration routes

This results in increased oxidative damage to neurons, impaired neuronal function, and the progression of the disease (Liu et al., 2024)

Sleep and Circadian Rhythm Support Epitalon is also known for its connection to pineal function, melatonin, and circadian rhythm

Frequently, the intraocular pressure lowering agents showed discordant effectiveness