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Most published topical studies have used concentrations between 1 percent and 3 percent

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The total amount of drug metabolised for this group of drugs is unaffected by either hepatic blood flow or by changes in protein binding

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It crosses the blood-brain barrier and activates the hepatocyte growth factor (HGF) / c-Met receptor pathway, a signaling system that governs neuron survival, synaptic formation, and neural circuit repair