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One unit of NOX activity was determined as the quantity of the enzyme required to release 1 nM of the superoxide anion for 1 min [22]

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To understand if hypoxia could be a stimulus for mitophagy, we quantified mitolysosomes after acute OHT, finding significantly greater mitolysosome number in cells positive for pimonidazole, an adduct formed in cells exposed to hypoxia