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12 These hormones are able to bind to the PXR and when they do, the body increases its production of CYP3A4 and the hormones in question will be metabolized more rapidly.13 Therefore, the PXR creates a negative feedback loop which effectively places a thermostat on the hormonal system to maintain consistent levels of certain hormones

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Kassahun K, Mattiuz E, Nyhart E Jr, Obermeyer B, Gillespie T, Murphy A, et al