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B12 deficiency is especially risky for vegetarians, the elderly, and people with absorption issues, such as those with Crohns disease.

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Research community sources commonly describe rotating injection sites (abdomen, outer thigh, back of upper arm) to lower the chance of local irritation

Importantly, folic acid should not be given alone before B12 deficiency is excluded or treated, as this can mask anaemia while allowing neurological damage to progress

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