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Safety and Side Effects Common Side Effects The most commonly reported side effects of oral lysine supplementation are gastrointestinal in nature and dose-dependent: Diarrhea: Reported at doses of 1 gram or more daily [7][11] Abdominal pain and cramping: Reported at doses of 1 gram or more daily [7][11] Nausea: Occasionally reported, particularly when taken on an empty stomach at higher doses These side effects are generally mild and manageable by taking lysine with food or reducing the dose

Stassen HH, Bridler R, Hgele S, Hergersberg M, Mehmann B, Schinzel A et al (2000)

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