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Aco1 and Leu1 protein levels were quantified by western blot using polyclonal antiAco1, a gift from Anne Bulteau (Paris, France), and antiLeu1, a gift from Rolland Lill (Marburg, Germany), antibodies

Phase II Conjugation Reactions Phase II metabolism involves the conjugation of a bioactive drug or its phase I metabolites with large polar molecules to enhance solubility and elimination