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Signaling through these isoforms results in: i

The -ketoglutarate dehydrogenase complex in cancer metabolic plasticity

They mostly live in the oxygen-free colon, housed and fed by the outer mucus layer, in a mutualistic relation with their host and hundreds of other species, difficult to replicate in a Petri dish

Skin ageing results from the alteration of redox equilibrium triggered by multiple interconnected processes, including biochemical reactions, genetic factors, and external stimulation, and contributes to the occurrence of ageing and age-related diseases [122]

Our attempts to obtain X-ray co-crystal structures of TGR and inhibitors resulted in structures with no detectable density of the inhibitors, possibly owing to the limited solubility of the compounds in the crystallization conditions