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In the middle cerebral artery occlusion (MCAO) model, mice treated with ferroptosis inhibitors exhibit reduced brain damage, indicating that ferroptosis contributes significantly to post-ischemic neuronal death

The consumption of glutamine by the cancer cells in clear cell renal cell carcinoma (ccRCC) results in the local deprivation of extracellular glutamine This, in turn, triggers the release of IL-23 by cancer-infiltrating macrophages via the activation of hypoxia-inducible factor 1 (HIF1) [71]

Glutathione as a Treatment Avenue If glutathione depletion is part of the problem, can replenishing it help

Accordingly, these principles have been therapeutically exploited in nanomedicine platforms designed to induce GSH-dependent ROS amplification (Fig

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