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They postulate the pain felt by patients is out of proportion to the damage seen, the pain is not just because cartilage over the bone gets worn down. They state the thin rim of the cartilage becomes inflamed and sends pain signals to the body

We identified the candidate gr mutant firstly by observing fragment size in a PCR analysis, and all observed PCR fragments were in accordance with the predicted sizes as described in the Materials and Methods section (Figure 6A)

Skin biopsy specimens (T 0 and T 1 ) from PS participants will be collected from a psoriatic lesion area (different regions of lesion occurrence) and a non-lesion area (right lower quadrant of the abdomen), while from healthy individuals, a skin specimen will be collected at the right lower quadrant of the abdomen

Methods Human pluripotent cell lines The use of the iPSC and ESC lines was reviewed by the Harvard Committee on the Use of Human Subjects (the Harvard IRB) and determined to not constitute human subjects research