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Low expression levels of CISD1 and CISD2 limit the Fe 3+ content in mitochondria, thereby inhibiting ferroptosis

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This hormonal sensitivity explains why certain scalp regions are affected while others, like the back and sides, typically remain resistant throughout life

Some individuals are more GI-sensitive than others

However, many other forbidden disulfides share this property, so this does not explain why evolution of CSDs is favored over other forbidden disulfides