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Jia Y, Cai S, Muhoza B, Qi B, Li Y

Irisin was revealed to have neuroprotective effects on PD by activating the ERK, P38MAPK and AMPK pathways and then upregulating Nrf2, HO-1, and Bcl-2 independently of NF-B, reducing the release of cytokines and the NLRP3 inflammasome and Caspase-1 [87]