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Studies have found that acupuncture can effectively reverse the CUMS-induced decline in Nrf2, HO-1, and GPX4 levels in the hippocampus of rats, reduce the activation of astrocytes and microglia, and alleviate depression-like behavior induced by CUMS

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Even so, it was demonstrated that the primary mechanisms by which psychobiotics exert their effects include HPA axis regulation, immune response and inflammation modulation, and neurohormone and neurotransmitter synthesis as depicted in Figure 5 (70)

Yang D, Xiao P, Qiu B, Yu HF, Teng CB