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FIGURE 3 TABLE 1 H and C attribution and comparison between compounds 5 and 6

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(Hort.) thesis, Kerala Agricultural University, Thrissur

By inducing degradation of cIAPs, SMAC mimetics triggers formation of the TRADD-RIPK1-FADD-caspase8 signaling complex, resulting in caspase 8 activation and apoptosis [167]