is glutathione primarily intracellular Cellular Compartmentalization, Transport and Its Relevance in Some Pathologies is glutathione primarily intracellular Glutathione:

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[Google Scholar] 113.Song Y., Leonard S.W., Traber M.G., Ho E

Here, we have utilized liver-specific overexpression of cation transport regulator homolog 1 (Chac1), a recently identified intracellular GSH-degrading enzyme, to induce hepatic GSH depletion during MASLD progression

In mitochondria, wherein NADH is abundant, NNT-derived NADPH is estimated to account for half of the NADPH, and NNT-knockdown alters mitochondrial redox status [11]