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When cirrhosis develops, a state of hepatic GH resistance ensues resulting in high GH and low IGF-I levels (125) ( Figure 1E )

Mechanistic and Translational Research Further investigation into the molecular mechanisms of action could help optimize clinical applications and identify novel therapeutic targets

Ice applied for 10 to 15 minutes before injection can numb the area and reduce discomfort, though some patients prefer heat after injection to minimize post-injection soreness

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Therefore, regulating ROS levels may be an important strategy for controlling ferroptosis and related diseases