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For now, we will simply observe that if electron transport is inhibited for some reason, yet the NADH/NAD + ratio remains significantly elevated above its equilibrium mass action ratio, then electrons may leave the electron transport chain and move onto O 2 to create O 2 .- Other physiologic changes in mitochondria may also increase ROS generation without necessarily dramatically affecting oxidative phosphorylation

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62 and performed as described previously (11, 63)

Rejection of highly efficacious therapies