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Mercapturic acids: recent advances in their determination by liquid chromatography/mass spectrometry and their use in toxicant metabolism studies and in occupational and environmental exposure studies

doi: 10.1111/nyas.14468 5 ShenDYLiJHuPQiCYangH

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For instance, using a series of inducible and tissue-specific transgenic constructs with a bacterially-derived enzyme -- methioninase, which degrades methionine to ammonia, -ketobutyrate, and methanthiol -- to reduce in vivo methionine, Parkhitko and others found that they could both investigate the consequences of whole body and tissue-specific reduced methionine levels ( Branched-chain amino acids A group of three other essential amino acids, the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine, have also drawn interest due to their known impact on protein synthesis, food intake, and metabolic health (Vellai et al., 2003