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The MT superfamily combines a large variety of small Cys-rich proteins that have the ability to coordinate various transition metal ions, including Zn 2+ , Cd 2+ , and Cu + (Freisinger, 2011)

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Recently, greater clinical benefit has been seen with the use of albumin-bound sirolimus (nab-sirolimus, FYARRO) in the treatment of PEComa: 39% of patients had PRs, with median duration of response of 40 months, and there was a 7% complete response rate (including a patient with surgical resection of residual disease) (44)

The 125 mg suppositories are particularly suitable for children who have difficulty taking medications orally , offering rapid relief thanks to rectal absorption