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Pathogenic mutations decrease the affinity of SOD1 toward the metal ions and/or the stability of the disulfide bond [16, 17], thereby disturbing the native conformation of SOD1

Consequently, current therapies are reactive rather than preventive, highlighting the critical need for disease-modifying treatments that target underlying pathophysiology

OC is a complex disease that can be classified into five main subtypes: HGSOC, low-grade serous OC, serous, clear cell and mucinous (52)

In summary, ROS serves as a double-edged sword in cancer

Why NYC Residents Are at Higher Risk of Glutathione Depletion Life in New York City, with its unique blend of environmental and lifestyle factors, places residents at an elevated risk of experiencing glutathione depletion