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This process is marked by the loss of activity of the lipid repair enzyme glutathione peroxidase 4 (GPX4), accompanied by the buildup of lipid ROS (115)

And those include a lot of diseases that are part of the human, the realistic human longevity story

10.1016/S0167-7799(97)01076-7 59 GoutP

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Loren Pickart in 1973, the GHK-Cu copper peptide was isolated based on observations that plasma from younger individuals contained factors that influenced liver cell behavior differently than plasma from older individuals