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The success of GSB-106 in reversing depressive behaviors in animal models further supports BDNF as a causal factor

In most cases, treatment for B12 deficiency is effective, and a person will not continue to have symptoms

Furthermore, we found that SC97, a major activator of brain-permeable Akt1 phosphorylation 34 , also significantly attenuated sulindac-induced GABAergic neuronal apoptosis (Supplementary Fig